PURE NUTRITION L-GLUTATHIONE 250mg antioxidant Boosts the immune system x 60 caps
Glutathione exists in cells in two states: reduced (GSH) and oxidized (GSSG). The ratio of GSH to GSSG determines the cellular reduction state of the cells. Healthy cells have a GSH/GSSG ratio > 100, while the ratio drops to 1 to 10 in cells exposed to oxidative stress. Glutathione is also recognized as a thiol buffer, maintaining the sulfhydryl groups of many proteins in their reduced form. Glutathione is produced exclusively in the cytosol and is actively pumped into mitochondria. It plays a crucial role in the protection of cellular macromolecules from endogenous and exogenous reactive oxygen and nitrogen species. Although it directly suppresses some free radicals, it may be more important that it addresses the causes of oxidative stress, such as mercury. Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the pathogenesis of many diseases (including Alzheimer's disease, Parkinson's disease, liver disease, cystic fibrosis, sickle cell anemia, COPD, stroke and diabetes). Understanding the cellular regulation of GSH metabolism is crucial for developing effective strategies for improving health and treating these diseases. Perhaps the best indicator of the importance of glutathione is that its cellular and mitochondrial levels are directly linked to health and longevity.