CLAMSILIN for normal blood clotting x 30 sachets
Clampsillin is a combined synergistic formula that contributes to the health of the cardiovascular system and good blood circulation of the mother and fetus. It also contributes to normal blood clotting and to the normal metabolism of homocysteine and lipids.
Manufactured in Spain according to the best manufacturing practices and the most current scientific achievements, Clampsilin combines the thoroughly researched effects of 5 active ingredients:
· L-arginine base is an amino acid in its pure form without any additional compounds, naturally occurring in free form.
· Calcium is recommended by the WHO "as part of prenatal care to prevent preeclampsia among pregnant women, especially among those at higher risk of hypertension."
· The choline bitartrate in the Clampsilin formula is choline combined with tartaric acid. This increases its bioavailability, making it easier to absorb and more effective.
· The crystallized organic lutein in Clampsilin is isolated from marigold flowers and is created using a patented technology that ensures maximum concentration, absorption and bioavailability.
· Vitamin D is a hormone-like fat-soluble vitamin that is attracting increasing scientific interest due to its broad-spectrum effect on the course of pregnancy and the health of the mother and fetus.
Features:
· Promotes cardiovascular health and blood circulation of the mother and fetus.
· Contributes to the vascular function of the placenta.
· Has a positive effect on blood clotting and fat metabolism.
· Helps control blood pressure.
· Counteracts oxidative stress.
· Free of allergens.
· GMO-free.
Active ingredients (in 1 sachet):
L-arginine base: 1500 mg
Calcium carbonate: 1300 mg, providing 513.5 mg calcium (64% NRV*)
Choline Bitartrate: 800 mg, providing 325.6 mg choline
Marigold dry extract (Tagetes erecta L., flower): 50 mg, providing 10 mg lutein
Cholecalciferol: 6 mg, providing 15 μg of vitamin D (300% NRV*)
Composition:
L-arginine, choline bitartrate, maltodextrin, natural coloring (beetroot red, betanin), lutein, strawberry flavor, emulsifier (silicon dioxide), sweeteners (sucralose, stevia), natural flavor, citric acid, vitamin D.
Recommended dosage:
Take one (1) to two (2) sachets of Clampsilin per day.
Pour the contents of the sachet into a glass of water (about 200 ml), stir and drink. If sediment appears, add a little more water, stir and drink again.
Packaging: 30 sachets of 4000 mg
Preeclampsia: suspected causes and potential approaches
Preeclampsia is one of the most common complications of pregnancy, usually associated with high blood pressure and protein in the urine. Its causes are not fully understood, but placental, immune, and vascular factors, as well as oxidative stress, are thought to play a role.
Inadequate blood supply to the placenta leads to impaired vascular function, which results in secondary changes in a number of organs and a multitude of distressing symptoms. Although in most cases the final outcome is favorable, preeclampsia can be life-threatening for both the mother and the fetus (Say et al., 2014).
That is why medical science is intensively researching various drug approaches, lifestyle changes, and nutraceutical agents that may be helpful in the prevention and management of this condition.
L-arginine
Nitric oxide (NO) is a potent vasodilator and its production has been shown to be impaired in preeclampsia (Morris & Eaton, 1996). It is known that nitric oxide-mediated vasodilation is necessary during pregnancy for the regulation of maternal blood pressure, systemic circulation, and adequate placental blood supply to support fetal growth. NO synthesis is necessary to reduce the risk of hypertensive complications associated with pregnancy, including preeclampsia and eclampsia (Goodrum et al., 2003).
The main site for nitric oxide production is in endothelial cells, using the body's stores of L-arginine. Therefore, the availability of this amino acid in the body may be key to preventing blood vessel constriction in preeclampsia.
L-arginine is considered a semi-essential amino acid because, at elevated needs, endogenous synthesis is not sufficient to meet the body's requirements (Visekр 1986). Furthermore, pregnancy is a state of relative arginine deficiency imposed by the increased formation of NO for the physiological needs of pregnancy and the increasingly rapid rate of L-arginine consumption by the fetus (Conrad et al., 1993).
Studies of L-arginine in preeclampsia have found significant improvements in maternal and fetal hemodynamics and concluded that L-arginine has a positive effect on the prevention of preeclampsia (Hishikawa et al., 1992; Pulido et al., 2016). Meta-analyses have reported significant reductions in maternal blood pressure when arginine is added in gestational hypertension and preeclampsia (Facchinetti et al., 2007).
Calcium
According to the WHO, “calcium supplementation as part of prenatal care is recommended to prevent preeclampsia among pregnant women, especially among those at higher risk of hypertension.”
This recommendation is based on evidence from meta-analyses of randomized clinical trials that found that calcium supplementation prevents approximately half of preeclampsia. The guidelines recommend daily supplementation of 1–2 g of calcium from 20 weeks of gestation onwards, depending on dietary calcium intake. Daily intake of calcium carbonate in divided doses of ≤500 mg calcium is recommended (WHO Guideline, 2013; Moshood et al., 2016).
Supplementation of 500 mg of calcium daily for more than 6 months has been found to reduce the risk of preeclampsia by 45% (Khanam et al., 2018). The mechanism of action of calcium supplementation involves modulating placental blood supply and vascular function.
Low calcium intake reduces its plasma concentration, which leads to activation of the renin-angiotensin-aldosterone system (RAAS) and stimulates the release of a number of factors causing blood vessel constriction and high blood pressure (Villa-Etchegoyen et al., 2019).
Vitamin D
A recent meta-analysis of 27 randomized clinical trials with 4,777 participants concluded that vitamin D supplementation was associated with a reduced risk of preeclampsia (Fogacci et al., 2020).
An even more comprehensive meta-analysis of 55 studies shows that higher vitamin D concentrations during pregnancy may be associated with a reduced risk of preeclampsia and preterm birth (Aguilar-Cordero et al., 2020).
A review of 91 meta-analyses found a reduced risk of developing preeclampsia in pregnant women who took vitamin D supplements alone or in combination with calcium (Kinshella et al., 2021).
Choline
Choline is a water-soluble essential nutrient required for the synthesis of a number of molecules that support rapid cell division and modulate fetal growth and placental and brain development. Therefore, choline requirements are increased in pregnant women, and its deficiency can cause serious medical conditions such as premature birth, cystic fibrosis, and hepatosteatosis (Kansakar et al., 2023).
Early preeclampsia is associated with altered placental DNA methylation, and there may be a link between choline as a major methyl donor and dysregulated placental methylation. Recent data suggest that choline supplementation contributes to the reduction of antiangiogenic factor (sFLT-1), which is elevated in preeclampsia (Cohen et al., 2015).
High intake of choline (930 mg, approximately twice the current recommended intake) during the second and third trimesters of pregnancy has been shown to improve placental vascular function and “alleviate some of the pathologies associated with preeclampsia.” (Jiang et al., 2013)
Lutein
Lutein is an organic pigment from the carotenoid family that can counteract oxidative stress in the uterus and thus help prevent complications such as preeclampsia, intrauterine growth restriction, premature births, and other problems.
This is evidenced by randomized controlled trials, according to which supplementation with L-arginine and antioxidants reduces the incidence of preeclampsia in high-risk women (Vadillo-Ortega et al., 2011).
Furthermore, low lutein levels are known to be associated with both early and late preeclampsia, outlining the antioxidant's promising role in the prevention of this condition (Cohen et al., 2015).
Contraindications: Do not use in children under 6 years of age. Do not use in case of hypersensitivity to any of the ingredients.
Storage conditions: Store in a dry place at room temperature.
Warnings: Do not exceed the recommended daily dose. Do not use the food supplement as a substitute for a varied diet. Keep out of reach of small children. People taking medication should consume the product only under medical supervision. Do not use after the expiration date.
This product contains natural ingredients, therefore there may be a variation or change in the color of the powder, which should not be a cause for concern.
Manufacturer: Plantapol, Polígono Industrial Los Royales altos C/G 14 50171 La puebla de Alfindén, Zaragoza, Spain, Tel: 97608010 /Fax 976108188
Distributor: Naturpharma Bulgaria, Sofia, 21 Yanko Sofiyski Str., tel: +35929633359
