NATURPHARMA PROXEL POTENT for prostate and sexual function x 60 caps
NATURPHARMA PROXEL POTENT for prostate and sexual function x 60 caps
Proxel Potent is a NEW combination of two natural solutions for the health and self-esteem of the mature man, formulated on the basis of plant extracts, vitamins, minerals and amino acids with proven action:
- Proxel is our established product, in which for the first time we introduced 7 active ingredients in the form of a capsule to the market in order to help the Bulgarian man in the care of the prostate and fight against a common problem - benign prostatic hyperplasia .
- Potent is a completely new formula that complements and extends the action of Proxel. In it, in an innovative way, 5 bioactive natural substances are combined with a scientifically tested effect on erection, libido and the overall sexual performance of men in adulthood.
Taken together in just 1 capsule per day, Proxel & Potent charge the male organism with a cocktail of 12 active ingredients of decisive importance for urological and sexual health . Their safety and benefits in addressing one of the most common causes of complaints, frustration and reduced quality of life in men over 40 have been extensively documented in science and repeatedly confirmed in practice.
Features:
- 2 in 1: the first ever combined care for urological and sexual health.
- 12 natural ingredients: plant extracts, vitamins, minerals and amino acids.
- Each of the ingredients has been scientifically tested for effectiveness in "male" problems such as benign enlarged prostate, prostatitis (inflammation of the prostate), prostate cancer , erectile dysfunction, decreased libido and low testosterone levels.
- A non-hormonal product with an excellent safety profile even with long-term use.
- Just 1 capsule a day to help the prostate and male potency.
- Made in Spain.
Composition of Proxel (in 1 capsule):
- Pumpkin seed extract ( Cucurbita pepo ): 120 mg
- Dry extract of Asian centella ( Centella asiatica ): 100 mg
- Boswellia extract ( Boswellia serrata ): 50 mg
- Helichrysum extract ( Helichrysum italicum ): 50 mg
- Hyaluronic acid: 25 mg
- Tea tree extract ( Melaleuca alternifolia ): 1 mg
- Vitamin E (DL-alpha tocopheryl acetate): 12 mg
Excipients: maltodextrin (stabilizer), magnesium stearate, microcrystalline cellulose, thixosil (emulsifiers).
Composition of Potent (in 1 capsule):
- L-arginine: 200 mg
- Dry extract of maca (Lepidium meyenii): 200 mg
- Dry extract of Tribulus Terrestris (Tribulus Terrestris, granny's teeth): 100 mg containing 40 mg of saponins
- Dry extract of Asian ginseng (Panax ginseng): 75 mg containing 3.75 mg ginsenosides
- Zinc oxide: 18.99 mg containing 15 mg zinc
Excipients: microcrystalline cellulose (filler), magnesium stearate (anti-caking agent).
Active ingredients in Proxel and prostate health
Centella asiatica extract : back at the end of the last century, giving centella asiatica extract to mice with cancer was shown to shrink tumors and significantly increase life expectancy. In 2006, Gurfinkel et al. found that this effect was likely due to asiatic acid inducing cell death in isolated in vitro prostate cancer cells. The most recent review publications summarize the evidence for the potential effects of asiatic acid on a number of cancer mechanisms and confirm its serious prophylactic and therapeutic potential (Nagoor Meeran et al, 2018).
Boswellia extract : active compounds called boswellic acids are responsible for the extract's anti-inflammatory and cell-protective properties. A number of studies have tested acetyl-11-keto-B-boswellic acid (AKBA) and found that it suppresses the growth of a wide range of tumors, including prostate (Syrovets et al., 2000).
In 2008, Yuan and colleagues demonstrated that AKBA reduces androgen receptor activity, which is key to the development and progression of prostate carcinoma. Acetyl-11-keto-B-boswellic acid also suppresses angiogenesis (the growth of new blood vessels, which is particularly intense in malignant tissues), thus depriving tumors of the resources they need for their development (Pang et al, 2009).
Pumpkin seed extract acts as an inhibitor of the enzyme 5-alpha reductase, which is responsible for converting the hormone testosterone into the more potent androgen dihydrotestosterone. This is a sought-after effect in certain androgen-dependent conditions, including benign prostatic hyperplasia (BPH), prostate cancer, and baldness (androgenic alopecia).
A one-year study conducted in Germany by Vahlensieck and colleagues in 2015 found that the administration of pumpkin seed extract resulted in a significant improvement in BPH and quality of life. Other studies have shown that pumpkin seed oil protects against prostatic hyperplasia, in addition to being beneficial in the treatment of benign prostatic hyperplasia (Gossell-Williams et al., 2006). Pumpkin seed oil also has a positive effect on sexual and reproductive function when used in combination with vitamin E, also available in the Proxel formula (Hashemi, 2013).
Helichrysum extract (yellow sedum): acetophenones, flavonoids and phloroglucinols have a pronounced anti-inflammatory effect, suppressing various pathways of inflammatory mediators.
Tea tree extract and vitamin E have a potent antioxidant effect and protect cells from oxidative stress. Tea tree oil has an antibacterial effect thanks to the terpinen-4-ol and cineole it contains.
Hyaluronic acid helps to better transport the active substances in the body. It attracts and retains water, contributes to the hydration and protection of tissues.
Active ingredients in Potent and male sexual function
Erectile dysfunction is a condition that affects the self-esteem and quality of sex life of one in five men over the age of 20 and one in two men between the ages of 40 and 70 (Selvin, Burnett & Platz, 2007; Colson et al, 2018). While advancing age is the most significant risk factor for erectile dysfunction, a number of other underappreciated factors contribute to this problem, such as smoking, excessive alcohol consumption, urinary tract infections, low testosterone, depression, anxiety, obesity, diabetes, cardiovascular disease, and hypothyroidism. (Colson, et al., 2018; Rastrelli et al., 2018; Chen et al., 2018).
In its essence, an erection is a blood filling of the penis, which takes place after the muscles of the cavernous body, extending along the male genital organ, relax. A major role in this relaxation is the release of an increased amount of nitric oxide under the influence of sexual arousal, which leads to the expansion of blood vessels (vasodilation) in the penis (Leung, Christ & Melman, 2004).
Disturbances in this process are the main cause of erectile dysfunction. Practically all drugs for erection aim to restore normal vascular function and, in particular, vasodilation. A significant amount of scientific interest in the field of male sexual health in recent years has been directed at discovering effective and safe nutraceutical ways to increase nitric oxide (NO), the molecule responsible for the dilation of blood vessels in the male genitalia.
L-arginine is an amino acid that serves as a direct source of nitric oxide for the body. Men with erectile dysfunction were recently found to have significantly lower levels of L-arginine (Barassi et al., 2017). This gave further impetus to its research as a potential therapeutic solution and alternative to prescription pills for erection such as Viagra, the use of which does not always give a satisfactory effect (Friedman & Friedman, 2015) and is associated with side effects such as headache, dyspepsia , abdominal pain , impaired vision, metabolic disorders, facial flushing, and in rare cases – and serious events such as heart attack and stroke (Ückert, Kuczyk & Oelke, 2013).
A significant volume of studies on L-arginine has accumulated in a short time, and an overview of their results can be found in a meta-analysis published in 2019 in The Journal of Sex Medicine (Rhim et al., 2019). Based on data from 10 randomized controlled trials with a total of 540 participants, L-arginine supplementation was found to significantly affect erectile dysfunction, increase sexual satisfaction, and improve orgasmic function .
All interventions registered excellent tolerability of the supplement. Another important finding is that combining L-arginine with other ingredients enhances its action . This reveals the potential of the amino acid to serve as a starting point for the formulation of a combination of ingredients with a synergistic effect on erectile function and libido.
Maca is an example of such an ingredient, traditionally used by the Incas as a means of increasing physical endurance and sexual potency. Known to botanists by its Latin name Lepidium meyenii , it is a member of the Cruciferous family and is cultivated for its root rich in bioactive compounds.
A 2009 pilot experiment (Stone et al., 2009) put the reasons for its traditional popularity to the test, measuring improvements in endurance and libido in a group of athletes after a 2-week intake of maca root extract. The bad news is that no progress has been registered in terms of durability. The good news is that all participants report a greatly increased sexual appetite . Another study with a large group of healthy adult men confirmed these results, showing a significant increase in libido after eight weeks of daily intake of maca extract (Gonzales et al., 2002).
The observed effect was also validated in patients with post-SSRI sexual dysfunction – reduced sensitivity, erectile function and libido as a result of treatment with antidepressants. Taking maca for 12 weeks helped participants significantly improve their sexual performance, with the effect being dose-dependent – proportional to the amount of extract taken (Dording et al., 2008).
Dry maca extract is also effective in men with diagnosed erectile dysfunction, with significant improvements in erectile function and sexual well-being measured according to the International Index of Erectile Function (IIEF-5) and Satisfaction Profile ( SAT-P) (Zenico et al., 2009).
Tribulus terrestris ( Tribulus terrestris ) is an herb of traditional Ayurvedic medicine, better known among our herbalists as "granny's teeth". Long used as a male health enhancer, it has an almost mythical fame in the field of strength and sex athletes of yesterday and today.
It turns out that this fame is not without a cover. Although its halo of a sports supplement has not been scientifically validated, there is convincing evidence for its properties on the sexual front. In 2005, tribulus extract was found to stimulate male sex hormone receptors in the brain and increase the number of a special class of neurons involved in nitric oxide production (Gauthaman & Adaikan, 2005). This finding reveals a plausible biological mechanism for the herb's positive effect on both libido and erection .
One of the first studies to test the clinical effect of taking sage was conducted on 63 men with oligozoospermia (low sperm count). After 12 months of intake, not only an improvement in sperm characteristics, but also a significant increase in erectile qualities and frequency of intercourse was recorded (Sellandi, Thakar & Baghel, 2012).
In men with partial androgen deficiency, erectile dysfunction and low libido, taking tribulus extract for 3 months resulted in an increase in testosterone levels and erectile function as measured by the International Index of Erectile Function-5 (IIEF-5) (Roaiah et al ., 2016).
In a follow-up experiment, 180 men with erectile dysfunction took elderberry extract or a placebo for 12 months. A significant improvement in the potency of those taking the herb began to be observed already after the fourth week, and at the end of the experiment, a nearly threefold better sexual function, as measured by the IIEF, was reported. Improvements were also reported in terms of sexual satisfaction and orgasmic function (Kamenov et al., 2017).
Its potential adaptogenic properties probably contribute to the effect of tribulus terrestris. Several experiments have found that an extract of the herb has comparable effects to some antidepressants, with its administration completely normalizing stress hormone levels in chronically stressed subjects (Wang et al., 2013; Deole et al., 2011).
Panax ginseng ( Panax ginseng , also known as Korean, Chinese, or Asian ginseng), specifically its root, has a centuries-old history in Eastern medicine, and some of its purported properties have been tested under controlled conditions. One of the effects that has been confirmed time and time again by scientific experiments is its positive impact on male potency. A number of studies have shown that Korean ginseng extract improves erectile function, affecting both psychogenic and vascular causes of sexual problems in men.
A pilot study of 60 patients with mild to moderate erectile dysfunction found that 12 weeks of daily ginseng extract resulted in better erections in 66.6% of participants (De Andrade et al., 2007). Another double-blind placebo-controlled experiment with a larger sample confirmed that regular intake of panax ginseng over a period of 8 weeks improved potency and sexual function (Kim et al., 2009).
The accumulation of a critical mass of ginseng extract studies warrants critical reading. In 2008, the first systematic review of evidence on the effectiveness of the herb was published, which included a total of seven experiments on men with erectile dysfunction (Jang et al., 2008). The authors concluded that ginseng is effective in treating this condition. A subsequent systematic review from 2011 confirmed these findings and further found that ginseng has a good safety profile and the incidence of side effects from its use is low (Lee & Son, 2011).
A separate line of research on the effects of Panax ginseng on the male reproductive organs showed that the root extract of the plant increased protein synthesis in the testes (Yamamoto, Kumagai & Yamamura, 1977), minimized the harmful effects of alcohol on testicular function (Jang et al., 2011) and stimulates spermatogenesis and sperm motility in infertile men (Salvati et al., 1996).
Zinc is an essential dietary mineral that fulfills numerous roles in the human body – it catalyzes a number of reactions and plays the role of a structural component in hundreds of metalloproteins.
It has long been known that the levels of zinc in the body are directly related to the levels of testosterone , and increased excretion of zinc in the urine carries the risk of lowering the male sex hormone (Prasad et al., 1996; Chang et al., 2011; Zeng et al., 2013). This is important because testosterone is deeply involved in every phase of the male sexual response , its low levels being one of the factors of sexual dysfunction in men (Rastrelli, Corona & Maggi, 2018).
Clinical studies in zinc-deficient men found that oral zinc intake for 6 weeks increased testosterone levels by 84% (Jalali et al., 2010). Adding zinc to the diet of infertile men with low testosterone levels significantly increased sex hormone levels, with 25% of couples conceiving within 3 months of the trial (Netter, Nahoul & Hartoma, 1981).
Taking 15 mg of zinc in athletes with normal testosterone levels resulted in increased testosterone levels immediately after exercise (Neek, Gaeini & Choobineh, 2011). This is important because physical overexertion can lead to a drop in hormone levels. The effect has been confirmed in both non-athletic men and elite athletes after exhaustive training – in both scenarios, supplemental zinc keeps sex hormone status intact (Kilic, 2007; Kilic et al., 2006).
Recommended dosage:
Take the combination of 1 Proxel capsule and 1 Potent capsule daily, preferably during or immediately after a meal.
Recommended therapeutic course : 3-6 months.
Package:
Proxel: 30 capsules (2 blisters x 15 capsules)
Potency: 30 capsules (2 blisters x 15 capsules)
Do not use in case of hypersensitivity to any of the ingredients. The product is a food supplement. Do not exceed the recommended daily dose. The product is not a substitute for a varied diet. Keep out of the reach of small children. Do not use after expiry date. Storage: In a dry place, at a temperature below 25 degrees.
Manufacturer : Plantapol SL · Pol. Ind. Malpica Alfindén, G 18 50171 - La Puebla de Alfindén, Zaragoza (Spain)
