NATURPHARMA PROXEL POTENT for prostate and sexual function x 60 caps
NATURPHARMA PROXEL POTENT for prostate and sexual function x 60 caps
Proxel Potent is a NEW combination of two natural solutions for the health and self-confidence of the mature man, formulated based on plant extracts, vitamins, minerals and amino acids with proven effects:
- Proxel is our established product, in which we first introduced 7 active ingredients to the market in capsule form with the aim of helping Bulgarian men care for their prostate and fight a common problem - benign prostatic hyperplasia .
- Potent is a completely new formula that complements and expands the action of Proxel. It innovatively combines 5 bioactive natural substances with scientifically proven effects on erection, libido and overall sexual performance of adult men.
Taken together at just 1 capsule per day, Proxel & Potent fuel the male body with a cocktail of 12 active ingredients with a decisive importance for urological and sexual health . Their safety and benefits in addressing some of the most common causes of complaints, frustration and impaired quality of life in men over 40 have been extensively documented in science and repeatedly confirmed by practice.
Features:
- 2 in 1: the first-of-its-kind combined care for urological and sexual health.
- 12 natural ingredients: plant extracts, vitamins, minerals and amino acids.
- Each of the ingredients has been scientifically tested for effectiveness in "male" problems such as benign enlarged prostate, prostatitis (inflammation of the prostate), prostate cancer , erectile dysfunction, decreased libido, and low testosterone levels.
- Non-hormonal product with an excellent safety profile even with long-term use.
- Just 1 capsule daily to help the prostate and male sexual power.
- Made in Spain.
Proxel composition (in 1 capsule):
- Pumpkin seed extract ( Cucurbita pepo ): 120 mg
- Dry extract of Asian centella ( Centella asiatica ): 100 mg
- Boswellia extract ( Boswellia serrata ): 50 mg
- Helichrysum extract ( Helichrysum italicum ): 50 mg
- Hyaluronic acid: 25 mg
- Tea tree extract ( Melaleuca alternifolia ): 1 mg
- Vitamin E (DL-alpha tocopheryl acetate): 12 mg
Excipients: maltodextrin (stabilizer), magnesium stearate, microcrystalline cellulose, thixosil (emulsifiers).
Ingredients of Potent (in 1 capsule):
- L-arginine: 200 mg
- Dry extract of maca (Lepidium meyenii): 200 mg
- Dry extract of Tribulus Terrestris (Tribulus Terrestris, elderberry): 100 mg containing 40 mg of saponins
- Dry extract of Asian ginseng (Panax ginseng): 75 mg containing 3.75 mg of ginsenosides
- Zinc oxide: 18.99 mg containing 15 mg zinc
Excipients: microcrystalline cellulose (filler), magnesium stearate (anti-caking agent).
Active ingredients in Proxel and prostate health
Centella Asiatica Extract : As early as the end of the last century, it was shown that giving centella Asiatica extract to cancer-bearing mice led to tumor shrinkage and significantly longer lifespan. In 2006, Gurfinkel et al. discovered that this effect was likely due to asiatic acid, which induces cell death in isolated in vitro prostate cancer cells. Recent review publications summarize the evidence for the potent effects of asiatic acid on a number of cancer mechanisms and confirm its serious prophylactic and therapeutic potential (Nagoor Meeran et al, 2018).
Boswellia extract : Active compounds called boswellic acids are responsible for the extract’s anti-inflammatory and cell-protective properties. A number of studies have tested acetyl-11-keto-B-boswellic acid (AKBA) and found that it inhibits the growth of a wide range of tumors, including prostate tumors (Syrovets et al., 2000).
In 2008, Yuan and colleagues demonstrated that AKBA reduced androgen receptor activity, which is key to the development and progression of prostate cancer. Acetyl-11-keto-B-boswellic acid also inhibits angiogenesis (the growth of new blood vessels, which is particularly intense in malignant tissues), thereby depriving tumors of the resources they need to grow (Pang et al, 2009).
Pumpkin seed extract acts as an inhibitor of the enzyme 5-alpha reductase, which is responsible for converting the hormone testosterone into the more potent androgen dihydrotestosterone. This is a sought-after effect in some androgen-dependent conditions, including benign prostatic hyperplasia (BPH), prostate cancer, and baldness (androgenic alopecia).
A one-year study conducted in Germany by Vahlensieck et al. in 2015 found that pumpkin seed extract significantly improved BPH and quality of life. Other studies have shown that pumpkin seed oil protects against prostatic hyperplasia and may be beneficial in the treatment of benign prostatic hyperplasia (Gossell-Williams et al., 2006). Pumpkin seed oil also has a positive effect on sexual and reproductive function when administered in combination with vitamin E, also present in the Proxel formula (Hashemi, 2013).
Helichrysum extract (yellow smyl): acetophenones, flavonoids and phloroglucinols have a pronounced anti-inflammatory effect, suppressing various pathways of inflammatory mediators.
Tea tree extract and vitamin E have potent antioxidant effects and protect cells from oxidative stress. Tea tree oil has antibacterial effects, thanks to the terpinen-4-ol and cineole it contains.
Hyaluronic acid helps to better transport active substances in the body. It attracts and retains water, helping to hydrate and protect tissues.
Active ingredients in Potent and male sexual function
Erectile dysfunction is a condition that affects the self-esteem and quality of sex life of one in five men over the age of 20 and one in two men between the ages of 40 and 70 (Selvin, Burnett & Platz, 2007; Colson et al, 2018). While advancing age is the most significant risk factor for erectile dysfunction, a number of other underappreciated factors such as smoking, excessive alcohol consumption, urinary tract infections, low testosterone, depression, anxiety, obesity, diabetes, cardiovascular disease, and hypothyroidism contribute to this problem (Colson, et al., 2018; Rastrelli et al., 2018; Chen et al., 2018).
Essentially, an erection is the filling of the penis with blood, which occurs after the muscles of the corpus cavernosum, which extend along the male genital organ, relax. A major role in this relaxation is played by the release of increased amounts of nitric oxide under the influence of sexual arousal, which leads to the expansion of blood vessels (vasodilation) in the penis (Leung, Christ & Melman, 2004).
Disturbances in this process are a major cause of erectile dysfunction. Virtually all erection medications aim to restore normal vascular function, and in particular, vasodilation. A significant portion of scientific interest in the field of male sexual health in recent years has been directed at discovering effective and safe nutraceutical ways to increase nitric oxide (NO), the molecule responsible for the dilation of blood vessels in the male genital organ.
L-arginine is an amino acid that serves as a direct source of nitric oxide for the body. It was recently found that men with erectile dysfunction have significantly lower levels of L-arginine (Barassi et al., 2017). This has given further impetus to its research as a potential therapeutic solution and alternative to prescription erection pills such as Viagra, the use of which does not always give a satisfactory effect (Friedman & Friedman, 2015) and is associated with side effects such as headache, dyspepsia , abdominal pain , impaired vision, metabolic disorders, facial flushing, and in rare cases – serious events such as heart attack and stroke (Ückert, Kuczyk & Oelke, 2013).
A significant amount of research on L-arginine has accumulated in a short time, and a meta-analysis published in 2019 in The Journal of Sex Medicine (Rhim et al., 2019) provides an overview of their results. Based on data from 10 randomized controlled trials with a total of 540 participants, it was found that L-arginine supplementation significantly affects erectile dysfunction, increases sexual satisfaction, and improves orgasmic function .
All interventions recorded excellent tolerability of the supplement. Another important finding is that combining L-arginine with other ingredients enhances its effect . This reveals the potential of the amino acid to serve as a starting point for the formulation of a combination of ingredients with a synergistic effect on erectile function and libido.
Maca is an example of such an ingredient, traditionally used by the Incas as a means to increase physical endurance and sexual potency. Known to botanists by its Latin name Lepidium meyenii , it is a member of the Cruciferae family and is cultivated for its root, which is rich in bioactive compounds.
A 2009 pilot study (Stone et al., 2009) tested the reasons for its traditional popularity by measuring improvements in endurance and libido in a group of athletes after 2 weeks of taking maca root extract. The bad news is that no progress was recorded in terms of endurance. The good news is that all participants reported a greatly increased sexual appetite . Another study with a large group of healthy adult men confirmed these results, showing a significant increase in libido after eight weeks of daily maca extract intake (Gonzales et al., 2002).
The observed effect has also been validated in patients with post-SSRI sexual dysfunction – decreased sensation, erectile function and libido as a result of antidepressant treatment. Taking maca for 12 weeks helped participants to significantly improve their sexual performance, with the effect being dose-dependent – proportional to the amount of extract taken (Dording et al., 2008).
Dry maca extract is also effective in men with diagnosed erectile dysfunction, with significant improvements in erectile function and sexual well-being, measured according to the International Index of Erectile Function (IIEF-5) and Satisfaction Profile (SAT-P), reported after a 12-week course of intake (Zenico et al., 2009).
Tribulus terrestris is a herb from traditional Ayurvedic medicine, better known among our herbalists as "grandmother's teeth". Long used as a means of improving men's health, it has an almost mythical fame in the field of strength and sex athletes of yesterday and today.
It turns out that this fame is not without its flaws. Although its halo as a sports supplement has not been scientifically validated, there is convincing evidence for its properties on the sexual front. In 2005, it was found that taking tribulus extract stimulates male sex hormone receptors in the brain and increases the number of a special class of neurons involved in the production of nitric oxide (Gauthaman & Adaikan, 2005). This finding reveals a plausible biological mechanism for the herb's positive effect on both libido and erection .
One of the first studies to test the clinical effects of taking fenugreek was conducted on 63 men with oligozoospermia (low sperm count). After 12 months of taking it, not only was there an improvement in sperm characteristics, but also a significant increase in erectile function and frequency of intercourse (Sellandi, Thakar & Baghel, 2012).
In men with partial androgen deficiency, erectile dysfunction, and low libido, taking tribulus extract for 3 months led to increased testosterone levels and erectile function, measured by the International Index of Erectile Function-5 (IIEF-5) (Roaiah et al., 2016).
In a subsequent experiment, 180 men with erectile dysfunction took either fenugreek extract or a placebo for 12 months. Significant improvements in potency were observed in those taking the herb after the fourth week, and at the end of the experiment, nearly three times better sexual function, as measured by the IIEF, was reported. Improvements were also reported in terms of sexual satisfaction and orgasmic function (Kamenov et al., 2017).
Tribulus terrestris’s effects are likely due to its potent adaptogenic properties. Several experiments have found that the herb extract has comparable effects to some antidepressants, with its intake completely normalizing stress hormone levels in subjects subjected to chronic stress (Wang et al., 2013; Deole et al., 2011).
Panax ginseng ( Panax ginseng , also known as Korean, Chinese or Asian ginseng), specifically its root, has a centuries-old history in Eastern medicine, and some of its alleged properties have been tested under controlled conditions. One of the effects that has been confirmed time and again by scientific experiments is its positive impact on male potency. A number of studies have shown that Korean ginseng extract improves erectile function, affecting both psychogenic and vascular causes of sexual problems in men.
A pilot study of 60 patients with mild to moderate erectile dysfunction found that 12 weeks of daily ginseng extract resulted in improved erections in 66.6% of participants (De Andrade et al., 2007). Another double-blind placebo-controlled trial with a larger sample size confirmed that regular intake of Panax ginseng for a period of 8 weeks improved potency and sexual function (Kim et al., 2009).
The accumulation of a critical mass of studies with ginseng extract necessitates a critical reading. In 2008, the first systematic review of evidence on the effectiveness of the herb was published, which included a total of seven trials on men with erectile dysfunction (Jang et al., 2008). The authors concluded that ginseng is effective in treating this condition. A subsequent systematic review in 2011 confirmed these conclusions and, in addition, found that ginseng has a good safety profile and the incidence of side effects when used is low (Lee & Son, 2011).
A separate line of studies on the effects of Panax ginseng on male reproductive organs shows that the extract from the plant's root increases protein synthesis in the testes (Yamamoto, Kumagai & Yamamura, 1977), minimizes the harmful effects of alcohol on testicular function (Jang et al., 2011), and stimulates spermatogenesis and sperm motility in men suffering from infertility (Salvati et al., 1996).
Zinc is an essential dietary mineral that performs numerous roles in the human body – it catalyzes a number of reactions and plays the role of a structural component in hundreds of metalloproteins.
It has long been known that zinc levels in the body are directly related to testosterone levels , and increased urinary zinc excretion poses a risk of lowering the male sex hormone (Prasad et al., 1996; Chang et al., 2011; Zeng et al., 2013). This is important because testosterone is deeply involved in every phase of the male sexual response , and low levels are one of the factors for sexual dysfunction in men (Rastrelli, Corona & Maggi, 2018).
Clinical studies on zinc-deficient men found that oral zinc supplementation for 6 weeks increased testosterone levels by 84% (Jalali et al., 2010). Adding zinc to the diet of infertile men with low testosterone levels significantly increased sex hormone levels, with 25% of couples conceiving within 3 months of the trial (Netter, Nahoul & Hartoma, 1981).
Supplementation of 15 mg of zinc by athletes with normal testosterone levels resulted in increased testosterone levels immediately after exercise (Neek, Gaeini & Choobineh, 2011). This is important because physical exertion can lead to a decline in hormone levels. The effect has been confirmed in both non-athletic men and elite athletes after exhaustive exercise – in both scenarios, supplemental zinc preserved sex hormone status (Kilic, 2007; Kilic et al., 2006).
Recommended dosage:
Take the combination of 1 Proxel capsule and 1 Potent capsule daily, preferably during or immediately after a meal.
Recommended therapeutic course : 3 – 6 months.
Packaging:
Proxel: 30 capsules (2 blisters x 15 capsules)
Potent: 30 capsules (2 blisters x 15 capsules)
Do not use in case of hypersensitivity to any of the ingredients. The product is a food supplement. Do not exceed the recommended daily dose. The product is not a substitute for a varied diet. Keep out of the reach of small children. Do not use after the expiration date. Storage: In a dry place, at a temperature below 25 degrees.
Manufacturer : Plantapol SL · Pol. Ind. Malpica Alfindén, G 18 50171 - La Puebla de Alfindén, Zaragoza (Spain)
