NATURPHARMA THYROHELP for normal thyroid function x 30 caps
Thyrohelp / Tirohelp is a food supplement with a specially created formula, including the amino acid L-tyrosine, zinc, selenium, vitamin D and a standardized extract of turmeric, which contributes to the normal function of the thyroid gland and the immune system.
This is the first formula of this type in Bulgaria. Its ingredients are selected for their high safety profile, natural origin and solid evidence of effectiveness. Each one of them individually is often recommended by specialists and preferred by patients in the fight against an increasingly common problem - thyroid gland dysfunction. In Thyrohelp, they are optimally combined so that they provide a significant intake for the body, complementing each other and enhancing their beneficial effect.
Until recently, it was thought that the risk of hypothyroidism and hyperthyroidism was determined mostly by dietary iodine intake. But modern science recognizes more and more factors that influence it: age, smoking, genetic predisposition, ethnicity, endocrine disruptors (eg BPA and other xenoestrogens), some new treatments and drugs (eg immune checkpoint inhibitors), and more.
According to recent estimates, over 5% of thyroid dysfunctions remain undiagnosed. This is especially true for the elderly, where the percentage is up to twice as high. About 2/3 of undiagnosed thyroid dysfunctions are types of hypothyroidism (Lucas, A., et al., 2010; Diab, N., et al., 2019). The sex more at risk is decidedly the fairer, with women having up to 10 times the risk of hypothyroidism and up to 12 times the risk of hyperthyroidism compared to men. (Vanderpump, M., 2011; Diab, N., et al., 2019).
Composition (in 1 capsule)
- L-Tyrosine (proteinogenic amino acid): 250 mg
- Turmeric extract (Curcuma longa, 95% curcumin): 75 mg
- Zinc (zinc sulfate - 41.66 mg): 15 mg
- Selenium (sodium selenite): 100 mcg
- Vitamin D (cholecalciferol): 10 mcg
Excipients: microcrystalline cellulose (emulsifier), silicon dioxide, magnesium stearate (anti-caking agents).
What Science Says About Thyroid and…
L- tyrosine
Tyrosine is used by the body in combination with iodine to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Therefore, the addition of L-tyrosine (one of the natural isomers of the amino acid) to the diet of patients with hypothyroidism is a common practice.
In a 2007 experiment, Palinkas and colleagues found that supplementing with L-tyrosine increased T3 levels in 85 volunteers placed under stressful conditions. In addition, decreased levels of TSH, whose high values are usually associated with hypothyroidism and chronic stress, are also observed. These results are also supported by animal model experiments in which supplemental L-tyrosine improves neuroendocrine function and prevents a decline in thyroid hormone levels under conditions of chronic stress (Wang, Z, et al., 2012)
L-tyrosine significantly improves and preserves alertness, psychomotor function, and cognition in extreme situations and in chronic sleep deprivation (Deijen, et al., 1999; Neri, et al., 1995). These effects are likely due to its effects on a number of neurotransmitters and hormones such as melatonin, dopamine and/or norepinephrine and could be of clinical relevance to patients suffering from hypothyroidism.
Curcumin
The antioxidant and anti-inflammatory properties of curcumin have been well studied (Venugopal & Sudheer, 2007). It was recently found that thanks to them, a standardized extract of turmeric can protect the thyroid gland from damage and thus contribute to the maintenance of stable thyroid hormone levels (Abdelaleem, M, et al., 2018).
Elevated levels of T3 can cause increased oxidative stress in the body, and curcumin has been shown to effectively counteract this stress and associated damage (Samanta, L, et al., 2010).
Benign thyroid nodules (thyroid nodules) are one of the most common endocrine disorders. A recent trial from neighboring Romania showed that curcumin supplementation significantly reduced the size of these nodules after only a 6-week intake period (Stancioiu, F, et al., 2019).
Zinc
The mineral zinc is closely related to thyroid function in more ways than one. When zinc levels in the body are low, it stops the formation of THR and TSH, resulting in low levels of T4 and T3. Zinc is also a constitutive component of the enzyme deiodinase, which converts T4 to functional T3. If there is a lack or deficiency of the mineral in the body, the formation of T3 is difficult or even impossible. (Baltaci, A, et al., 2004; Khanam, S, 2018; Severo, J, et al., 2019). Zinc is known to be required for the normal functioning of the T3 receptor as well, and low levels of zinc in this receptor can lead to impaired function of the T3 hormone (Freake, H, et al. 2001).
In addition, low zinc levels are associated with increased autoimmunity - high levels of anti-thyroid antibodies - TPO and Tg - are observed in zinc-deficient thyroid patients (Ertek S, et al. 2010).
A number of reports indicate that zinc deficiency is a cause of subclinical hypothyroidism. Addition of zinc to the diet of patients with Down syndrome results in improved thyroid function (Napolitano, G, et al., 1990). In animal model experiments, hypothyroidism has been found to result in impaired zinc absorption (Chen, S, et al., 2005). Supplemental zinc has beneficial effects on thyroid hormone levels (especially total T3), metabolic rate (Maxwell, C. & Volpe, SL, 2007) and a number of hypothyroid symptoms such as depression, decreased mental acuity, hair loss, decreased appetite and skin lesions ( Betsy, A, et al., 2013).
A 2015 study of 68 hypothyroid women found that zinc supplementation increased free T3 levels, and the combination of zinc and selenium significantly decreased TSH and increased T4 (Mahmoodianfard, S, et al., 2015).
Selenium
Did you know that the thyroid gland is the organ with the highest levels of selenium in the entire body? It is well known that maintaining normal physiological levels of selenium is key to its proper functioning and prevention of thyroid diseases (Ventura, M., et al., 2017). Low levels of the mineral worsen the negative consequences of iodine deficiency (Arthur, JR, 1991), are associated with subacute thyroiditis, as well as with the most common malignant tumors of the thyroid gland - papillary and follicular carcinoma (Moncayo, R., et al. , 2008). A recent cross-sectional study of over 6000 people found that low serum selenium levels were associated with an increased risk of autoimmune thyroiditis and hypothyroidism (Wu, Q., et al., 2015).
It has been repeatedly shown that selenium supplementation can contribute to the lowering of anti-thyroid antibodies, the improvement of the ultrasound structure of the thyroid gland, and the beneficial effect of autoimmune thyroiditis, including Hashimoto's (Toulis, KA, et al., 2010; Drutel, A ., et al., 2013; Ventura, M., et al., 2017).
Clinical improvement from selenium intake was also observed in patients with Based's disease (Drutel, A., et al., 2013), as well as in patients with mild to moderate thyroid-associated ophthalmopathy (Ventura, M., et al., 2017).
Vitamin D
Vitamin D insufficiency and deficiency are common conditions associated with autoimmune thyroid diseases such as Hashimoto's and Based's disease. Moreover, a number of thyroid tumors have been shown to be associated with disturbances in vitamin D signaling (Kim, D., 2017). The frequency of vitamin D deficiency is significantly higher in patients with autoimmune thyroiditis and probably plays a role in the pathogenesis of their conditions - a significant correlation was found between the presence of anti-thyroid antibodies and deficiency of the fat-soluble vitamin (Kivity, S., et al ., 2010).
Other studies have shown that patients with Hashimoto's have elevated levels of the same inflammatory molecules whose harmful effects are effectively blocked by adequate serum levels of vitamin D (Mikos, H., et al., 2017; Sun, L., et al., 2016; Makariou, S., et al., 2011)
So far, the evidence for vitamin D as a potential weapon in the fight against autoimmune thyroid disease is promising. A number of clinical trials have found that cholecalciferol supplementation beneficially affects anti-thyroid antibody and T4 levels (Chaudhary, S., et al., 2016; Simsek, Y., et al., 2016; Chaudhary, S., 2018 ).
Recommended dosage:
Take 1 Thyrohelp capsule daily.
Packaging: 30 gelatin capsules
Contraindications: Pregnancy, breastfeeding and children under 6 years old. Do not use in case of hypersensitivity to any of the ingredients.
Warnings: Do not exceed the recommended daily dose! The nutritional supplement should not be used as a substitute for a varied diet! Keep out of the reach of small children!
Storage conditions: Store in a dry place at room temperature.
Manufacturer: Plantapol – Spain, C/G 18, Pol.Malpica – Alfinden, La Puebla Del Alfinden Zaragoza, Spain
Distributor: "Naturpharma Bulgaria" EOOD, Sofia, 21 Yanko Sofiyski St., tel. 02/ 963 33 59, info@naturpharmabg.com
